In a mouse model, MMP9 deficiency resulted in resistance to endotoxin shock, suggesting that MMP9 is important in sepsis.
2.
In a mouse model, Gelatinase B deficiency resulted in resistance to endotoxin shock, suggesting that Gelatinase B is important in sepsis.
3.
Vascular inflammation can be caused by upregulation of LPS . Further elucidation of molecular mechanisms of LPS signaling, showed that Tyk2 and IFN-? deficiency leads resistance to LPS-induced endotoxin shock, whereas STAT1-deficient mice are susceptible.
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